It will depend on what you have done, what mods are on your truck and choice of octane. I had Rev, Speedlimiter, torque management, abuse mode and rear O2's all deleted. Had efan activated and tuned for 89 octane with CAI , exhaust and tire size recalculated as my only mods on all three of my trucks. 99 5.3 Sierra ECSB, 01 4.8 Sierra RCSB and my 06 5.3 Silverado SBCC. On the 99 and 01 I also had the operating system swapped to the 02 operating system.
I noticed the most gain on the 01 with the 4.8. All three run really well and bark 2nd with ease, but it turned the 4.8 into the funest to drive but like I stated, it was a 4.8 RCSB and the others were not and is most likley why it was more noticeable on it. Overall drivability was gained on all 3 and about 1.5 mpg.